Estradiol Patch
A small patch you wear on your skin that slowly releases estrogen into your bloodstream.
“The patch made it easy to forget about my symptoms. I change it twice a week and that’s it.”
How to Get It
Available at most retail and mail-order pharmacies. Generic versions often available.
Treatment Timeline
1–3 weeks for initial symptom relief; 8–12 weeks for full benefits
Insurance Details
Typically covered - can get coupons off GoodRX
$25–$75/month with insurance; $100–$150 without
More about
Estradiol Patch
What to Love
The patch is discreet, effective, and long-acting. Many women love the convenience—but it can occasionally cause skin irritation or fall off early. You may need to test a few brands to find one that sticks well.
How it Works
Apply to clean, dry skin—usually the lower abdomen or buttock. Replace once or twice weekly depending on the brand. Rotate sites to avoid irritation.
Estradiol patches release biosimilar estrogen through the skin, helping manage menopausal symptoms while avoiding the liver.
Patches provide a steady release of estrogen and are considered lower risk than oral estrogen for blood clots and stroke. They’re especially helpful for women with migraines, metabolic concerns, or trouble remembering daily meds.
When to Avoid
Avoid if you’ve had breast cancer, unexplained vaginal bleeding, or clotting disorders. Some adhesives may cause rashes for sensitive skin.
Possible Side Effects
Skin irritation, breast tenderness, headaches, spotting
Recommended Brands
Vivelle-Dot, Minivelle, Climara, Alora, generic estradiol
