Micronized Progesterone (Prometrium)
A nightly pill that protects the uterus when taking estrogen and may help with sleep and mood.
“It makes me drowsy—in a good way. I fall asleep easier, and it keeps me protected.”
How to Get It
Prescription only. Available at retail pharmacies. Generic versions available.
Treatment Timeline
Sleep benefits within days; uterine protection is ongoing
Insurance Details
$15–$50/month with insurance; ~$60–$90 without
More about
Micronized Progesterone (Prometrium)
What to Love
Micronized progesterone is gentle and effective. It’s often better tolerated than synthetic progestins and may offer bonus sleep support. Some women experience grogginess or mood changes, but for many, it’s a smooth ride.
How it Works
Take 100–200mg by mouth at bedtime, typically in combination with estrogen therapy
Micronized progesterone is a bioidentical hormone used to balance estrogen therapy and reduce the risk of endometrial cancer.
This form of progesterone is molecularly identical to what your body makes and is often preferred for its lower risk profile. It’s taken orally at bedtime and has a sedating effect for many women.
When to Avoid
Avoid if allergic to peanuts (Prometrium brand), or if you have a history of progesterone-sensitive cancers or clotting issues
Possible Side Effects
Drowsiness, grogginess, mood changes, spotting
Recommended Brands
Prometrium, generic progesterone capsules
