Synthetic Progestin (Medroxyprogesterone, etc.)
Lab-made progesterone-like hormones used to protect the uterus during estrogen therapy.
“I didn’t love how it made me feel emotionally, but it did the job.”
How to Get It
Prescription only. Readily available.
Treatment Timeline
Immediate for uterine protection; cyclical or daily depending on formulation
Insurance Details
Covered by most insurance.
10–$40/month with insurance; ~$50 without
More about
Synthetic Progestin (Medroxyprogesterone, etc.)
What to Love
They’re reliable and often prescribed—but some women are more sensitive to the side effects. If you notice mood swings or sleep issues, ask your provider about switching to micronized progesterone.
How it Works
Dose and schedule vary: some are taken daily, others in cycles. Follow provider instructions closely.
Synthetic progestins are effective at reducing endometrial cancer risk when taking systemic estrogen, but may come with more side effects than bioidentical forms.
These progestins are effective and widely used, but they differ chemically from natural progesterone and may be linked to slightly higher risks of mood issues, breast tenderness, and breast cancer (depending on the type and duration of use).
When to Avoid
Avoid if you have hormone-sensitive cancers, clotting issues, or known intolerance
Possible Side Effects
Mood swings, headaches, bloating, breast tenderness
Recommended Brands
Provera, Aygestin, Camila (norethindrone), generic options
