Vaginal Estrogen Cream
A low-dose estrogen cream applied inside the vagina to relieve dryness and discomfort.
“It took the edge off almost immediately. Sex doesn’t hurt anymore, and I feel more like myself.”
How to Get It
Available through most pharmacies.
Treatment Timeline
1–2 weeks for relief; best results in 4–8 weeks
Insurance Details
$25–$50/month with insurance; ~$100 without
More about
Vaginal Estrogen Cream
What to Love
This is often the first-line treatment for vaginal and urinary symptoms. It’s effective and fast-acting—but it can be messy or awkward for some to apply. Some creams need to be used several times a week, which requires consistency.
How it Works
Apply using a plastic applicator or your finger, usually at bedtime. Initial usage is often 2–3 times a week. Dose may be tapered for maintenance.
Vaginal estrogen restores moisture, thickness, and pH balance to the vaginal and urinary tissues without significantly affecting the rest of the body.
Vaginal estrogen works directly on the vaginal tissues and is not intended to treat whole-body symptoms. It’s very low-dose and considered safe for long-term use—even in women with a history of hormone-sensitive cancer, with approval from their doctor.
When to Avoid
Generally safe, even for breast cancer survivors with provider guidance. Avoid if you have unexplained vaginal bleeding.
Possible Side Effects
Initial irritation, discharge, spotting
Recommended Brands
Estrace, Premarin
