Estradiol Gel

A clear gel you apply to your skin daily to absorb estrogen through your bloodstream.

“I like that it dries fast and doesn’t interrupt my routine. I just rub it in after my shower.”

How to Get It

Most pharmacies carry it; you may need to specify your preferred brand.

Treatment Timeline

1–3 weeks for symptom relief; 8–12 weeks for full effect

Insurance Details

Often covered with prior authorization

$25–$60/month with insurance; $100–$150 without

More about

Estradiol Gel

What to Love

This is a great option for women who want control, flexibility, and lower cardiovascular risk. But it does require consistent application, and skipping a dose can reduce effectiveness. The gel dries quickly, but you’ll want to avoid showering or getting it on someone else’s skin for at least an hour.

How it Works

Apply the prescribed amount (usually a packet or pump) to clean, dry skin—commonly the inner thigh or upper arm. Let it dry before dressing. Wash hands after application.

Estradiol gel delivers bioidentical estrogen through the skin, bypassing the liver and reducing clot risk.

Topical estrogen therapies like gel offer steady hormone delivery without the blood sugar or clotting effects associated with oral estrogen. They’re especially useful for women who can’t tolerate pills, and are considered lower risk for those with elevated triglycerides or liver concerns.

When to Avoid

Avoid if you have a history of estrogen-sensitive cancers, untreated high blood pressure, or unexplained vaginal bleeding. Always consult your doctor.