Estradiol Spray

A fine mist that delivers estrogen through the skin via a small pump bottle.

“It felt high-tech. I just sprayed my inner arm, let it dry, and went on with my day.”

How to Get It

Available at many pharmacies, but may need to be ordered in advance.

Treatment Timeline

1–2 weeks for symptom relief; full effects within 8–12 weeks

Insurance Details

Sometimes covered; depends on the insurance plan

$40–$100/month with insurance; ~$150–$200 without

More about

Estradiol Spray

What to Love

This option is discreet and dries quickly with no mess. It requires careful application (same time/place each day) and can transfer if touched before drying. It’s newer and may not be covered by all insurance plans yet.

How it Works

Spray directly on the inside of the forearm at the same time daily. Do not rub in. Allow to dry fully before dressing or touching others.

This spray provides low-dose estradiol through the skin, offering flexibility and fast drying.

Like patches and gels, the spray avoids the digestive system and delivers estrogen steadily through the skin. It may be ideal for those who prefer fast-drying options or need small, adjustable doses.