SSRIs - Selective Serotonin Reuptake Inhibitors
Antidepressants that can also ease hot flashes and stabilize emotional ups and downs.
“The mood swings weren’t mine. The SSRI helped me feel like me again.”
How to Get It
Prescription required. Common and widely accessible.
Treatment Timeline
2–4 weeks for mood; 1–2 weeks for hot flashes (Brisdelle)
Insurance Details
$0–$20/month with insurance; $30–$80 without
More about
SSRIs - Selective Serotonin Reuptake Inhibitors
What to Love
These meds can be a lifeline—especially if you’re experiencing emotional shifts or can’t take hormone therapy. They may take a few weeks to work and can cause mild side effects at the start, but for many women, they bring real balance.
How it Works
Take orally, typically once daily. Best taken at the same time each day.
SSRIs can reduce hot flashes and improve anxiety, irritability, and depressive symptoms during menopause.
SSRIs affect serotonin, a neurotransmitter tied to both emotional and thermoregulatory regulation. Low-dose paroxetine (Brisdelle) is FDA-approved for hot flashes. Others may be used off-label for symptom relief.
When to Avoid
Avoid with MAOIs, in those with bipolar disorder (without a mood stabilizer), or if you’re highly sensitive to serotonin effects
Possible Side Effects
Nausea, insomnia, sexual side effects, dizziness, initial fatigue
Recommended Brands
Brisdelle (low-dose paroxetine), Lexapro, Zoloft, Prozac
