SNRIs - Serotonin-Norepinephrine Reuptake Inhibitors
Non-hormonal medications originally used for depression—but helpful for hot flashes and mood swings too.
“It didn’t take everything away, but it helped me feel more steady and less sweaty.”
How to Get It
Prescription required.
Treatment Timeline
Within 1–3 weeks for hot flashes; 4–6 weeks for mood
Insurance Details
Covered by most insurance plans.
$0–$30/month with insurance; $50–$100 without
More about
SNRIs - Serotonin-Norepinephrine Reuptake Inhibitors
What to Love
SNRIs are a strong option for women avoiding hormones or managing multiple symptoms at once. Side effects can include nausea or dizziness early on, but many adjust well within a few weeks.
How it Works
Take orally, once or twice daily depending on the medication. Taper slowly if stopping.
SNRIs can reduce the frequency and severity of hot flashes and may support mood and anxiety symptoms in menopause.
These medications work on serotonin and norepinephrine pathways in the brain. They’re commonly prescribed for people who can’t take hormone therapy, and have shown good efficacy in clinical trials for vasomotor symptoms.
When to Avoid
Avoid if you’re on MAOIs, have certain seizure disorders, or uncontrolled high blood pressure
Possible Side Effects
Nausea, dry mouth, sleep disturbances, dizziness, sexual side effects
Recommended Brands
Effexor XR, Pristiq, Cymbalta
