Non-hormonal medications originally used for depression—but helpful for hot flashes and mood swings too.
“It didn’t take everything away, but it helped me feel more steady and less sweaty.”
$0–$30/month with insurance; $50–$100 without
Prescription required.
Covered by most insurance plans.
Within 1–3 weeks for hot flashes; 4–6 weeks for mood
More about
SNRIs - Serotonin-Norepinephrine Reuptake Inhibitors
SNRIs are a strong option for women avoiding hormones or managing multiple symptoms at once. Side effects can include nausea or dizziness early on, but many adjust well within a few weeks.
SNRIs can reduce the frequency and severity of hot flashes and may support mood and anxiety symptoms in menopause.
These medications work on serotonin and norepinephrine pathways in the brain. They’re commonly prescribed for people who can’t take hormone therapy, and have shown good efficacy in clinical trials for vasomotor symptoms.
Avoid if you’re on MAOIs, have certain seizure disorders, or uncontrolled high blood pressure
Nausea, dry mouth, sleep disturbances, dizziness, sexual side effects
Take orally, once or twice daily depending on the medication. Taper slowly if stopping.
Effexor XR, Pristiq, Cymbalta
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