Lab-made progesterone-like hormones used to protect the uterus during estrogen therapy.
“I didn’t love how it made me feel emotionally, but it did the job.”
10–$40/month with insurance; ~$50 without
Prescription only. Readily available.
Covered by most insurance.
Immediate for uterine protection; cyclical or daily depending on formulation
More about
Synthetic Progestin (Medroxyprogesterone, etc.)
They’re reliable and often prescribed—but some women are more sensitive to the side effects. If you notice mood swings or sleep issues, ask your provider about switching to micronized progesterone.
Synthetic progestins are effective at reducing endometrial cancer risk when taking systemic estrogen, but may come with more side effects than bioidentical forms.
These progestins are effective and widely used, but they differ chemically from natural progesterone and may be linked to slightly higher risks of mood issues, breast tenderness, and breast cancer (depending on the type and duration of use).
Avoid if you have hormone-sensitive cancers, clotting issues, or known intolerance
Mood swings, headaches, bloating, breast tenderness
Dose and schedule vary: some are taken daily, others in cycles. Follow provider instructions closely.
Provera, Aygestin, Camila (norethindrone), generic options
FLUXX © 2025