A low-dose estrogen cream applied inside the vagina to relieve dryness and discomfort.
“It took the edge off almost immediately. Sex doesn’t hurt anymore, and I feel more like myself.”
$25–$50/month with insurance; ~$100 without
Available through most pharmacies.
1–2 weeks for relief; best results in 4–8 weeks
More about
Vaginal Estrogen Cream
This is often the first-line treatment for vaginal and urinary symptoms. It’s effective and fast-acting—but it can be messy or awkward for some to apply. Some creams need to be used several times a week, which requires consistency.
Vaginal estrogen restores moisture, thickness, and pH balance to the vaginal and urinary tissues without significantly affecting the rest of the body.
Vaginal estrogen works directly on the vaginal tissues and is not intended to treat whole-body symptoms. It’s very low-dose and considered safe for long-term use—even in women with a history of hormone-sensitive cancer, with approval from their doctor.
Generally safe, even for breast cancer survivors with provider guidance. Avoid if you have unexplained vaginal bleeding.
Initial irritation, discharge, spotting
Apply using a plastic applicator or your finger, usually at bedtime. Initial usage is often 2–3 times a week. Dose may be tapered for maintenance.
Estrace, Premarin
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